As with many things internet based, a lot of information is copied and pasted, has a dash of creative license, a sprinkling of Chinese whispers and boom you have a new superfood or a superherb. When we select our products we look for the most effective and the very best quality. So we research, then research some more, and provide all of that research here, so that you can make up your own mind.
Lions Mane has been suggested to have the potential to act as an anti-depressant, by balancing out the neurotransmitters responsible for depression. (20).
Studies suggest that Lions Mane has the ability to increase levels of Superoxide Dismutase (SOD) in human metabolism which helps reduce the accumulation of “lipofuscin” (a metabolic waste product that accumulates as we age). (12, 14)
It has been suggested that Lions Mane may help increase time to exhaustion in extended exercise environments, by making more glycogen available to tissues and increasing anti-oxidative enzyme activity, while also helping to reduce lactic acid and urea nitrogen which contribute to the onset of fatigue. (12)
Lions Mane polysaccharides had the ability to stimulate Macrophages which are part of the bodies immune response against infection. Where the beta-glucans have the ability to “induce” the maturation of dendritic cells, which are key in helping the body fight pathogens (bacteria / virus). (12, 14, 22)
A 2016 study suggested that Lions Mane had a positive impact mitochondrial function. (10)
By regulating cellular responses Lions Mane has the potential to mitigate the effects of inflammation and cell death as it has an impact on 4 bodily systems (circulatory, digestive, immune system and nerve system) which work together to help maintain homeostasis, thus lions mane has the potential to support complete health through regulation. (9) Another study suggests that Lions Man “systematically” helps the reduction of disease through effecting multiple pathways. (10)
Research suggests that the polysaccharides in Lions Mane have the ability to inhibit multiple negative effects on the gastrointestinal mucosa, helping maintain balance and preventing injury and ulcers. In conjunction with potentially helping mitigate the effects of the Helicobactor pylori gut bacteria, which has the ability to cause serious issues, including; two type of cancer (the rare MALT lymphoma and a stomach cancer called gastric adenocarcinoma) and peptic ulcers. (8, 12, 13, 14, 15, 17, 21)
Research in 2017, suggests that Lions Mane may be used to help mitigate the effects of hyperglycaemic activity in diabetic’s, although they suggest that further research be carries out on humans to understand the mechanism and potential use as a Nutraceutical intervention. (8, 12, 16)
A 2018 study has suggested indicated that supplementing with Lion Mane can help improve recognition memory and motor function when supplements orally, with the potential to be used in neurodegenerative diseases such as Alzheimers. (4, 10, 12) Research also suggests the reduction of the accumulation of Reactive Oxygen Species (ROS) which can cause oxidative stress. (10, 12, 19)
It has been suggested that Lions Mane may provide neuroprotective effects on the brain which can involve neurotransmitter modulation. (10, 12, 18, 19)
NEUROTROPHIC (NERVE HEALTH)
Neurotrophic factors are important in promoting the growth and differentiation of neurons. Water extracts of Lions Mane have been shown to have the potential to regenerate peripheral nerves in subjects with crush injuries. (2, 6, 11) Another study illustrates that Lions Mane has the potential to be used in neurological diseases such as alzheimers as it has the ability to increase Nerve Growth Factor (NGF) proteins in the brain. (3, 5, 7, 11, 12, 14, 18, 19)